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Chapter 7: Substitution Reactions

Introduction to Nucleophilic Substitution

11.12.2019

Topics Include:

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  • SN1 vs SN2

    • Reaction coordinate diagrams​

    • Reaction rate equations

    • Experimental determination

  • Nucleophilic Substitution - Role of the Electrophile, Role of the Nucleophile, and Reaction Stereochemistry

    11.13.2019

    Topics Include:

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    • Assessing the Electrophile​
    • Stereochemistry of SN1/SN2 Products
    • Assessing the Nucleophile

    Nucleophilic Substitution - Nucleophiles and Solvent

    11.14.2019

    Topics Include:

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    • Analysis of Nucelophiles for Substitution Reactions
    • Solvent choice for SN1 and SN2
    • Impact of solvents on nucleophiles

    Nucleophilic Substitution - Leaving Groups and Overview

    11.18.2019

    Topics Include:

    • Comparison of leaving groups
    • Converting poor leaving groups into good leaving groups
      • Tosylation
      • Protonation
    • Substitution Overview

    Practice Exam 2 Video Key

    11.18.2019

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